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HexOS is based on TrueNAS So yes

Watch NASCompares videos for DIY builds https://www.youtube.com/@nascompares

HexOS is based on TrueNAS, If they don't support it, then HexOS won't either Also, what would be the point? Mac Mini is probably the least flexible option for storage. You really don't want anything external for storage because of the risk of a thunderbolt cable getting unplugged.

One might ask why? Because it would might migrating from other system as simple as just adding in the drives from the old system and allowing a person to copy all the data off at sata/sas/nvme speed, and onto new drives in a new system whether they be internal or on an HBA with an external enclosure. Why would anyone do this you ask? Maybe their old hardware has failed but the drives are still good. It would be super handy for getting old data back again and/or faster migration off old hardware and able to reuse old drives

One might ask why? Because it would might migrating from other system as simple as just adding in the drives from the old system and allowing a person to copy all the data off at sata/sas/nvme speed, and onto new drives in a new system whether they be internal or on an HBA with an external enclosure. Why would anyone do this you ask? Maybe their old hardware has failed but the drives are still good. It would be super handy for getting old data back again and/or faster migration off old hardware and able to reuse old drives

Resilio Sync I am aware there is an "app" for it for TrueNAS. However trying to get it setup is ridiculous. I have tried every permutation of settings to get it working. Failed every time. The only reference that I could find to get Resilio Sync to work on TrueNAS is in Japanese and there's NO sub titles for it.

I have been a long time Netgear ReadyNAS owner, I started buying them not long after Netgear bought Infrant who originally made ReadyNAS. One of their BEST features was being able to setup backup jobs that use SMB. This is a huge feature that very few NAS's have. Why? You can back to/from a windows desktop/server file share. Because not everything has rsync Implementation of an rsync "gui" for backups is inconsistent between brands and makes setting up and rsync job a huge pain in the butt SMB is by far the fastest protocol on a ReadyNAS. My 628 model can sustain 9Gbps all day. Rsync on a ReadyNAS 628 barely gets 3Gbps, scp gets only 1.8Gbps While my Netgear 628 is old, unsupported and running an ancient kernal. I intend to use it until it dies with no spare parts able to be found for it. Readynas has been incredibly reliable for me, I've never had the hardware die on me. Just hard drives. I believe many other people would enjoy having backup jobs able to run via SMB as well.