i had same issue
I was playing around with my Router (GL-Net-Slate). I enabled AdGuard Home and told it to handle client requests. ie be my DNS (I think)
So I think it was looking up Hexos' request and not finding an IP/ blocking its traffic.
I stopped handling client requests, and it works again now.
(not sure if it was related, but I also shifted my NGINX HTTP/HTTPS ports from 80/443 to 30021/30022 and changed the router's port forwarding)