All I've heard is that USB components in general aren't built for sustained load, and may burnout and die, on USB drives specifically, the flash memory might die too. One dude said he had a graveyard pile of dead USB adaptors from when he thought he knew better.
But it'll otherwise work for some undetermined amount of time until then.
In data enters they use a cable that carries something like PCIe from the compute to a separate box with just a bunch of drives (JBOD)
So your idea is fine just not USB,, I'm not sure what's specifically available at a reasonable price though.